TAGMe DNA Methylation Detection no ka Pan-cancer
Nā hiʻohiʻona huahana
Lapaʻau liʻiliʻi invasive:E unuhi ma ka liʻiliʻi loa he 3mL Koko venous peripheral a i ʻole nā ʻano laʻana lapaʻau kūpono
pololei:Hoʻohana i ka ʻikepili nui a me AI algorithm, hoʻāʻo kikoʻī≥95%
ʻAno kūpono:Hiki i kekahi ʻike ke uhi i 25 mau maʻi maʻi maʻi kiʻekiʻe.
Kaʻina mua:Hoʻopili mai ka hōʻike ʻana o ka maʻi maʻi maʻi, ma ke kaʻina holoʻokoʻa o ka maʻi maʻi a me ka mālama ʻana.
ʻoluʻolu:E hoʻopaʻa i nā kūlana gula no ka ʻike ʻana i ka methylation - ʻenehana sequencing pyrophosphate, hiki ke hoʻopau i ka hoʻāʻo i loko o 4 mau hola.
Mana:Me 54 mau palapala ʻāina a me ka home, ua paʻi ʻia nā hopena noiʻi kūpono ma Cancer Research, Genome Research a me nā nūpepa kaulana ʻē aʻe.
Kumu ʻike
ʻO ka ʻike ʻana i ka maʻi kanesa holoʻokoʻa ʻo ka plasma ctDNA methylation test huahana i hoʻomohala ʻia e TAGMe, e koi ana ma kahi o 3ml o ke koko holoʻokoʻa e hopu pono a hoʻoholo i ke kūlana methylation o nā wahi kūlana kūikawā o ctDNA, i mea e hoʻokō ai i ka nānā mua a me ka nānā pono ʻana. o ke koko.
hana
I ka hōʻoia ʻana ma mua o 3000 mau lāʻau lapaʻau, ʻoi aku ka kiʻekiʻe o ka pae methylation o TAGMe i loko o nā ʻiʻo ʻōpū ma mua o nā kiko maʻamau.No laila, hiki ke hoʻohana ʻia ʻo TAGMe ma ke ʻano he hōʻailona pan-cancer i ka ʻike ʻana i nā maʻi maʻi like ʻole.
ʻO nā genes pili i ka histone i hypermethylated i ka maʻi kanesa a hiki i ka hypermethylated HIST1H4F ke lilo i mea biomarker pan-cancer.
--- Noi'i ma'i 'a'ai, IF: 12.7
Ma ke ʻano he hōʻailona pan-cancer, loaʻa iā TAGMe ka kikoʻī kiʻekiʻe a me ka naʻau i ka hōʻoia hōʻoia hōʻailona hōʻoia, nona ka waiwai kuhikuhi koʻikoʻi no ka maʻi maʻi o nā maʻi maʻi.
Paʻa ʻo TAGMe i nā ʻano ʻokoʻa ʻokoʻa inā ʻoi aku ka kikoʻī ma mua o 95%,
Nā hiʻohiʻona noiʻi
Moʻolelo ʻohana no ka maʻi kanesa:ʻO nā maʻi maʻi maʻi maʻi i nā ʻohana pili koke a i ʻole nā hoa pili.
ʻO ka maʻi viral a me nā maʻi mau loa:E like me HPV, HBV a me nā maʻi viral ʻē aʻe, polyps intestinal, gastritis atrophic mau loa a me ka cirrhosis ate, etc.
Hōʻike ʻia i ke kaiapuni carcinogenic no ka manawa lōʻihi:Hōʻike ʻia i ke kaiapuni radiation a i ʻole nā kemika weliweli no ka manawa lōʻihi.
ʻO ka hōʻailona tumor i manaʻo ʻia:e like me ka hoʻokahe koko ʻole ʻana, ka hematochezia, ka mimi, nā nodules māmā, ke kuni haʻahaʻa haʻahaʻa ʻole i wehewehe ʻole ʻia, a i ʻole ka emaciation, etc.
ʻO nā hana ola lōʻihi maikaʻi ʻole: ʻO ka puhi paka lōʻihi a i ʻole ka puhi ʻana, ka inu nui, ka ʻai wela a i ʻole ka inu wela, ka ʻai ʻana i ka paʻakai kiʻekiʻe, pickled, moldy, puhi a me nā meaʻai palai, etc.
E nānā pono i nā kūlana olakino:no ka hui ma luna o 40
