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huahana

TAGMe DNA Methylation Detection Kits (qPCR) no ka maʻi maʻi maʻi endometrial

ʻO ka wehewehe pōkole:

Hoʻohana ʻia kēia huahana no ka ʻike in vitro qualitative o hypermethylation o ke ʻanoPCDHGB7i loko o nā hōʻailona cervical.

ʻano hoʻāʻo: ʻO ka ʻenehana PCR nui ka fluorescence

ʻAno laʻana: Nā hiʻohiʻona wahine

Hoʻopili kikoʻī:48 hōʻike / pahu


Huahana Huahana

Huahana Huahana

NA HI'O HUA

pololei

NUI HUA (1)

Hoʻopaʻa ʻia ma luna o 800 mau lāʻau lapaʻau i loko o nā haʻawina ʻelua makapō multi-center, ʻo ka huahana kahi kikoʻī o 82.81% a me kahi sensitivity o 80.65%.

ʻoluʻolu

NUI HUA (2)

Hiki ke hoʻopau ʻia ka ʻenehana ʻike ʻike methylation Me-qPCR kumu i hoʻokahi ʻanuʻu i loko o 3 mau hola me ka ʻole o ka hoʻololi bisulfite.

Mamua

NUI HUA (4)

Hiki ke ʻike ʻia ma ka pae precancerous.

ʻOtometi

asfa

Hoʻohana ʻia me ka pulupulu cervical a me nā laʻana Pap smear.

KA MANAO ANA

Hoʻohana ʻia kēia kit no ka ʻike in vitro qualitative o ka hypermethylation o ka gene PCDHGB7 incervical specimens.ʻO ka hopena maikaʻi e hōʻike ana i ka piʻi ʻana o ka hopena o ka maʻi maʻi precancerous endometrial a me ka maʻi kanesa, kahi e pono ai ka nānā ʻana i ka histopathological o ka endometrium.ʻO ka mea ʻē aʻe, hōʻike nā hopena hōʻike maikaʻi ʻole i ka haʻahaʻa o ka hopena o ka endometrial precancerous lesions a me ka maʻi kanesa, akā ʻaʻole hiki ke kāpae ʻia ka pilikia.Pono e hoʻopaʻa ʻia ka ʻike hope loa ma nā hopena hoʻokolokolo histopathological o ka endometrium.ʻO PCDHGB7 kahi lālā o ka ʻohana protocadherin γ gene cluster.Ua ʻike ʻia ʻo Protocadherin e hoʻoponopono i nā kaʻina biological e like me ka hoʻonui ʻana o ka cell, cell cycle, apoptosis, invasion, migration and autophagy of tumor cells ma o nā ala hōʻailona like ʻole, a me kona silencing gene i kumu ʻia e ka hypermethylation o ka mea hoʻolaha e pili kokoke ana i ka hanana a me ka ulu ʻana. o na ma'i ma'i he nui.Ua hōʻike ʻia e pili ana ka hypermethylation o PCDHGB7 me nā ʻano ʻokoʻa like ʻole, e like me ka lymphoma non-Hodgkin, ka maʻi ʻaʻai umauma, ka maʻi maʻi cervical, ka maʻi maʻi endometrial a me ka maʻi maʻi ʻaʻai.

KUMU HOIKE

Loaʻa i kēia pahu ka mea hoʻoheheʻe nucleic acid a me ka reagent ʻike PCR.Hoʻokuʻu ʻia ka ʻakika nucleic e ka magnetic-bead-based method.Hoʻokumu ʻia kēia pahu ma ke kumu o ka fluorescence quantitative PCR, me ka hoʻohana ʻana i ka methylation-specific real-time PCR reaction no ka nānā ʻana i ka DNA template, a ʻike pū i nā pūnaewele CpG o PCDHGB7 gene a me ka marker control marker internal reference gene fragments G1 a me G2.Ua helu ʻia ka pae methylation o PCDHGB7 i ka laʻana, a i ʻole ka waiwai Me, e like me ka PCDHGB7 gene methylated DNA amplification Ct waiwai a me ka waiwai Ct o ka kuhikuhi.Hoʻoholo ʻia ka PCDHGB7 gene hypermethylation kūlana maikaʻi a maikaʻi ʻole paha e like me ka waiwai Me.

poaf

Nā hiʻohiʻona noiʻi

ʻO ka nānā mua

Nā kānaka olakino

Ka Loiloi Pilikia

ʻO nā pūʻulu pilikia nui (nā poʻe me ke kahe koko ʻokoʻa ma hope o ka menopause, ka mānoanoa endometrial, etc.)

Nānā Hoʻi hou

Ka heluna kanaka wānana

ʻO ke koʻikoʻi o ke kino

Ka nānā mua ʻana no ka heluna kanaka olakino:Hiki ke nānā pono ʻia ka maʻi maʻi endometrial a me nā ʻeha precancerous;

Ka loiloi pilikia no ka heluna kanaka pilikia nui:Hiki ke hoʻokō ʻia ka loiloi pilikia no ka poʻe me ke koko ʻokoʻa ʻole a me ka mānoanoa endometrial ma hope o ka menopause e kōkua i ka maʻi maʻi;

Ka nānā 'ana i ka heluna kanaka prognostic:Hiki ke hana ʻia ka nānā ʻana i ka heluna kanaka ma hope o ka hana ʻana no ka pale ʻana i ka lohi o ka mālama ʻana ma muli o ka hoʻi hou ʻana.

ʻOhi laʻana

ʻano laʻana: E kau i ka mea hoʻoheheʻe cervical ma ka cervical os, e hamo mālie i ka pulupulu cervical a hoʻololi i 4-5 mau manawa ma ka ʻākau, wehe mālie i ka pulupulu cervical, hoʻokomo i loko o ka solution mālama cell, a e lepili iā ia no ka nānā ʻana.

Mālama ʻia nā laʻana:Hiki ke mālama ʻia nā laʻana ma ka lumi wela a hiki i 14 lā, ma 2-8 ℃ a hiki i 2 mahina, a ma -20±5 ℃ a hiki i 24 mahina.

Kaʻina ʻike: 3 mau hola (me ka ʻole o ka hana lima)

S9 Flyer waihona liʻiliʻi

TAGMe DNA Methylation Detection Kits (qPCR) no ka maʻi maʻi maʻi endometrial

1b55ccfa3098f0348a2af5b68296773

Hoʻohana lapaʻau

ʻO ka hōʻailona kōkua hōʻailona o ka carcinoma endometrial

ʻAno ʻike

PCDHGB7

ʻAno laʻana

Nā hōʻailona cervical wahine

ʻano hoʻāʻo

ʻO ka ʻenehana PCR nui fluorescence

Nā hiʻohiʻona kūpono

ABI7500

Hoʻopili kikoʻī

48 hōʻike / pahu

Nā Kūlana Waihona

Pono e mālama ʻia ʻo Kit A ma 2-30 ℃

Pono e mālama ʻia ʻo Kit B ma -20±5 ℃

Pono a hiki i 12 mahina.

E pili ana iā mākou

Loaʻa i ka Epiprobe kahi hana hoʻomohala holoʻokoʻa: uhi ʻia ke kikowaena hana GMP i kahi ʻāpana o 2200 square meters, a mālama i kahi ʻōnaehana hoʻokele maikaʻi ISO13485, e hoʻokō i nā koi hana o nā ʻano huahana reagent hoʻāʻo genetic;uhi ka hale hana lapaʻau i kahi ʻāpana o 5400 square meters a loaʻa iā ia ka hiki ke hoʻokō i ka ʻoihana ʻike methylation cancer ma ke ʻano he keʻena lāʻau lapaʻau ʻekolu ʻaoʻao.Ma waho aʻe, loaʻa iā mākou ʻekolu mau huahana i loaʻa ka palapala CE, e uhi ana i ka maʻi maʻi cervical, ka maʻi maʻi endometrial a me ka ʻike pili pili i ka maʻi urothelial.

Hiki ke ho'ohana 'ia ka 'ike loea ma'i 'a'ai 'o Epiprobe no ka nānā 'ana i ka ma'i 'a'ai mua, ka 'ikepili kōkua, ka loiloi mua a me ka postoperative, ka nānā 'ana i ka ma'i 'a'ai, e holo ana ma ke ka'ina holo'oko'a o ka ma'i 'a'ai ma'i 'a'ai a me ka lapa'au 'ana, e hā'awi ana i nā ha'ina maika'i no nā kauka a me nā ma'i.


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